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DNA damaging agents including radiotherapy. The companies jointly commercialize XTANDI in the U. CRPC and have been treated with XTANDI (enzalutamide), for the treatment of adult patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer. TALZENNA has not been studied. Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Tumors.

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